New Orleans at Arizona (-2.5; 48.5) could decide two divisions. Seattle's stranglehold on the NFC West means that Arizona cannot start the season losing a home game. Conceivably to win the division, the Arizona Cardinals will have to win 11 or more games.
On the other side of the ball, a New Orleans Saints' loss does not put their chance to win the NFC South at much risk, but a win means they have rebounded from last season's sub-par showing and strong enough to win the division.
The Over/Under hinges on what type of game we get. If the Saints can score early and get the Cardinals to take more risks on both sides of the ball, take the Over with the Saints winning. Otherwise, take the Cardinals and the Under, results that prove the NFC West will be contested.
I really like this challenge for the Cardinals and select them with the Under. That is why this game barely edges Indianapolis Colts at Buffalo Bills as my game of the week.